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Updated: Jul 31, 2026

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在GPx4的膜接口的结合性通过反向小细胞片段选平台揭示

Courtney L Labrecque1, Brian Fuglestad1,2

  • 1Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 22384, United States.

bioRxiv : the preprint server for biology
|May 20, 2024
PubMed
概括

研究人员开发了一种新的选方法,使用模仿膜的反转来寻找外围膜蛋白的非共价药物联体. 这种方法确定了谷氨过氧化酶4 (GPx4) 的潜在抑制剂,这是癌症治疗的关键标.

关键词:
葡萄氨酸过氧化酶 4 氨酸过氧化酶蛋白质NMR是一种蛋白质NMR.基于碎片的药物发现.周边膜蛋白质是外围膜中的一种蛋白质.蛋白质 - 配体相互作用蛋白质 - 膜接口接口

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相关概念视频

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.