慢性重叠性疼痛症和诺基普拉斯性疼痛
Keira J A Johnston1, Rebecca Signer2, Laura M Huckins1
1Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT 06511, USA.
medRxiv : the preprint server for health sciences
|May 20, 2024
概括
慢性重叠疼痛症 (COPCs) 的共同因素 - - 诺基普拉斯疼痛是一种复杂的,遗传性特征. 基因分析确定了导致这种疼痛类型的关键变异和生物学途径,为其发展提供了见解.
科学领域:
- 遗传学 是一个遗传学.
- 疼痛医学 医学 疼痛医学
- 流行病学 流行病学
背景情况:
- 慢性重叠性疼痛症 (COPC) 经常同时发生,并且不成比例地影响女性和出生时被分配为女性 (AFAB) 的个人.
- 作为一种拟议的机械描述因素,诺西普拉斯痛可能是COPCs之间共同因素的基础.
- 目前对COPCs的研究缺乏对nociplastic疼痛的全面遗传研究.
研究的目的:
- 用现有的全基因组关联研究 (GWAS) 数据从六个COPCs.调查nociplastic疼痛的遗传结构.
- 为了确定与nociplastic疼痛相关的遗传变异和生物途径.
- 为了探索遗传相关性和组织/基因组丰富的nociplastic疼痛.
主要方法:
- 应用 GenomicSEM 共同因子 GWAS 和多变体转录全组关联 (TWAS) 分析到 COPC GWAS 数据.
- 通过链接失衡得分回归进行了基因相关性分析.
- 进行基因组和组织丰富分析.
主要成果:
- 确定了24个独立的单核酸多态 (SNPs) 和127个与鼻膜性疼痛相关的独特基因.
- 作为一个具有显著SNP遗传性的多基因特征,证明了nociplastic疼痛.
- 发现多部位慢性疼痛和nociplastic疼痛之间存在显著的遗传重叠,与类风湿性关节炎和神经病痛有较小的重叠.
结论:
- 鼻膜性疼痛是一种复杂的,遗传性特征,在某些慢性疼痛疾病中具有共同的遗传因素.
- 心脏和甲状腺组织,以及认知,人格和代谢特征,都涉及到无囊性疼痛机制.
- 这些发现有助于理解基因基础和潜在的机制的nociplastic疼痛的发展.
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