抗CV2/CRMP5自身免疫性疼痛的机制和治疗方法

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Updated: Jun 26, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

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Laurent Martin1,2, Harrison J Stratton1, Kimberly Gomez1

  • 1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, 85724 USA.

bioRxiv : the preprint server for biology
|May 20, 2024
PubMed
概括

在癌症患者中,对CV2 /ollapsin响应媒介蛋白5 (CRMP5) 抗原的自身免疫反应会导致疼痛的神经病变. 这项研究揭示了CV2 / CRMP5自身抗体直接增加感官神经元刺激性,导致疼痛.

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