Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pulmonary Hypertension and Kidney Disease: A Review of a High-Risk Patient Population.

Cardiology in review·2026
Same author

CGRP reception potentiates anxiety in an influenza A derived immune engram.

bioRxiv : the preprint server for biology·2026
Same author

Psychological Distress and Health-Related Quality of Life in Ménière's Disease: A Comparative Study in the Portuguese Population.

Journal of clinical medicine·2026
Same author

GLP-1 receptor agonists in stroke prevention: a narrative review on emerging therapeutic frontiers.

Annals of medicine·2026
Same author

Warm autoimmune hemolytic anemia in adults in Latin America: A scoping review.

Hematology, transfusion and cell therapy·2026
Same author

Geometric Monitoring of Steel Structures Using Terrestrial Laser Scanning and Deep Learning.

Sensors (Basel, Switzerland)·2026

相关实验视频

Updated: Jun 26, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.8K

神经元衍生型细胞因子 (INTERLEUKIN-34) 控制发育微质功能

Benjamin A Devlin, Dang M Nguyen, Gabriel Grullon

    bioRxiv : the preprint server for biology
    |May 20, 2024
    PubMed
    概括

    介质素34 (IL34) 是一种神经元细胞因子,对于支持成熟的微质细胞和正常的大脑发育至关重要. IL34调节微质成熟和突触修剪,影响神经元电路的形成.

    更多相关视频

    Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
    09:12

    Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

    Published on: January 30, 2014

    15.9K
    Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions
    08:47

    Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

    Published on: July 26, 2024

    2.0K

    相关实验视频

    Last Updated: Jun 26, 2025

    Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
    07:54

    Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

    Published on: April 13, 2017

    9.8K
    Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
    09:12

    Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

    Published on: January 30, 2014

    15.9K
    Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions
    08:47

    Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

    Published on: July 26, 2024

    2.0K

    科学领域:

    • 神经科学是一个神经科学.
    • 免疫学 免疫学 免疫学
    • 发展生物学 发展生物学

    背景情况:

    • 神经元 - 微质相互作用对大脑发育至关重要,但调节因素仍然不清楚.
    • 微质细胞,大脑的免疫细胞,在电路的形成和维护中起着至关重要的作用.

    研究的目的:

    • 为了研究神经元衍生的细胞因子IL34在调节出生后大脑发育期间的微质中的作用.
    • 了解IL34如何影响微质成熟,功能和突触消除.

    主要方法:

    • 在发育中的小鼠大脑中分析IL34mRNA和蛋白质表达.
    • IL34的遗传淘汰 (KO) 和微质标记物和行为的评估.
    • 在小鼠早期生命中的急性IL34阻塞和病毒过度表达实验.

    主要成果:

    • 在产后发育期间,IL34表达在神经元中增加,与微质成熟相关.
    • IL34 KO小鼠表现出不成熟的微质细胞和一个焦虑解消的表型.
    • IL34的操纵会影响突触的微细胞化,影响神经元电路的精细化.

    结论:

    • IL34是神经元 - 微质交叉的关键调节者在产后大脑发育.
    • IL34控制微质成熟,恒常功能和突触吞.
    • 这些发现凸显了IL34在建立健康的神经元电路中的关键作用.