与眼相关的兴奋网络激增是由皮质警觉状态塑造的
Sukru Demiral1, Christina Lildharrie1, Esther Lin1
1National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health.
Research square
|May 20, 2024
概括
自发的眼与大脑兴奋和网络活动的激增有关. 昏昏欲睡会改变这些反应,可能表明皮质处理延迟和唤醒效率降低.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 脑部成像 脑部成像
背景情况:
- 大脑动态受警觉状态和皮质网络兴奋度的影响.
- 兴奋的激增可以迅速改变大脑活动.
- 以前的研究将自发的眼睛闪与大脑唤起上升网络 (AAN) 和使用3TMRI的乳头激活联系起来.
研究的目的:
- 用高场7TMRI复制和扩展以前关于眼关联大脑活动的发现.
- 为了研究眼相关的兴奋激增和警觉状态 (警觉与昏昏欲睡) 之间的相互作用.
- 为了分析与眼相关的BOLD (血液氧气水平依赖) 活动,从人类结合体项目 (HCP) 的一个更大的队列中.
主要方法:
- 使用7TMRI休息状态扫描,同时从HCP队列中进行眼睛跟踪.
- 基于fMRI期间的瞳孔数据的分类警觉状态 (警觉/昏睡).
- 在预定义的感兴趣区域 (ROI) 中对BOLD信号进行了交叉相关性和闪事件分析,以及对整个大脑的voxel-wise分析.
主要成果:
- 大脑干中的BOLD峰值和thalamic核之间重复的积极交叉相关性与眼时刻重叠,眼后减少.
- 鉴定出最强烈的眼相关的BOLD激活在小脑,胰岛,侧生殖细胞核 (LGN) 和视觉皮层.
- 观察到,昏昏欲睡增强HRF BOLD,延迟时间到峰值,并突出了眼后的BOLD下降,随着区域反应能力的改变.
结论:
- 眼相关的兴奋激增调节大脑活动,在警觉状态和昏昏欲睡状态期间观察到不同的模式.
- 昏昏欲睡似乎会影响血液动力反应功能 (HRF) 和区域大脑网络参与.
- 观察到的差异表明,在昏昏欲睡期间皮质处理和唤醒效果的潜在变化,需要进一步调查.
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