高风险DCIS进展的瘤微环境决定因素
Alexander Borowsky1, Alexa Glencer2, Kirithiga Ramalingam2
1UC Davis.
Research square
|May 20, 2024
概括
了解管道癌 in situ (DCIS) 的进展是避免过度治疗的关键. 这项研究发现,免疫细胞与瘤细胞的接近以及肌皮层完整性是DCIS进展风险的关键因素.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 在位管道癌 (DCIS) 是侵袭性乳腺癌的前体,但只有一小部分进展.
- 识别预测DCIS进展的因素对于预防过度治疗和开发向治疗至关重要.
研究的目的:
- 描述瘤微环境和高风险DCIS病变的分子概况,这些病变没有进展到侵袭性癌症.
- 研究免疫透物,基因突变和肌皮细胞完整性在DCIS进展中的作用.
主要方法:
- 多重体免疫光被用来分析免疫细胞群和它们的空间分布.
- 整个外体序列测序和基因表达分析确定了突变和分子途径.
- 肌皮质连续性被评估,以评估管道屏障的完整性.
主要成果:
- 在高风险的DCIS中,PIK3CA和TP53的突变很常见.
- 更高的瘤透淋巴细胞 (TIL) 密度与TP53突变有关.
- 由于T细胞与瘤细胞的近距离,以及肌皮质连续性的减少与更好的结果相关,这表明免疫监测.
- 高水平的CD3+CD8-T细胞与良好的结果有关,而Treg细胞表明不良结果.
结论:
- 免疫微环境,特别是T细胞与瘤细胞的接近,以及肌上皮连续性是DCIS进展的重要决定因素.
- 肌皮层中的缺口可能会促进免疫细胞与瘤细胞的相互作用,从而影响疾病的结果.
- 这些发现突出了预防DCIS进展的潜在治疗目标.
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