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Updated: Jun 26, 2025

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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Published on: June 23, 2022

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α-Synuclein的翻译后修改修改了单体动力学和聚合动力学

Kasun Gamage, Binyou Wang, Eldon R Hard

    bioRxiv : the preprint server for biology
    |May 20, 2024
    PubMed
    概括

    翻译后的修改,如O-GlcNAcylation,对α-Synuclein聚合有不同的影响. 在T72的糖化减缓了聚合,而S87可能会加速早期阶段,表明修改不会在神经退行性疾病中均地影响蛋白质凝聚.

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