肠道微生物群诱导异常的氨基酸及其与糖尿病视网膜病变的相关性
Sheng-Qun Jiang1,2,3, Su-Na Ye1,2, Yin-Hua Huang1,2
1Aier Eye Hospital, Jinan University, Guangzhou 510000, Guangdong Province, China.
International journal of ophthalmology
|May 20, 2024
概括
肠道微生物群和代谢物与糖尿病视网膜病变 (DR) 的进展相关. 在PDR患者中,特定的细菌和改变的氨基酸/脂肪酸代谢可能为DR提供新的诊断标志物.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 眼科医生 眼科 眼科
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 了解DR的病理机制对于有效治疗至关重要.
- 肠道微生物群的改变越来越多地与各种疾病有关.
研究的目的:
- 研究肠道微生物组成,便代谢物和糖尿病视网膜病变 (DR) 的进展之间的相关性.
- 确定DR诊断和进展的潜在生物标志物.
- 阐明DR发展背后的新型病理机制.
主要方法:
- 从2型糖尿病患者中采集了便样本,这些患者有增殖性DR (PDR),非增殖性DR (NPDR),没有视网膜病变的糖尿病 (DM) 和健康的对照 (HC).
- 16S rDNA基因测序用于分析肠道微生物群结构.
- 使用非向代谢学 (LC-MS) 来分析便代谢物.
- 在微生物群和代谢物之间进行了相关性分析.
主要成果:
- 在这四组中,肠道微生物群的结构显著不同.
- 与DM和HC组相比,NPDR和PDR组的微生物群的多样性和丰富性减少了.
- 在PDR组中,特定的细菌 (例如,*Pseudomonas*, *Ruminococcaceae-UCG-002*) 被丰富.
- 在PDR患者中观察到氨基酸和脂肪酸代谢的改变,包括氨酸和氨酸的升高.
- 在*Ruminococcaceae-UCG-002*,*Christensenellaceae-R-7*和L-氨酸/氨酸水平之间发现了积极的相关性.
结论:
- 肠道微生物群组成和便代谢物概况与DR严重程度有关.
- 无序的氨基酸和脂肪酸代谢是PDR的特征.
- 特定的肠道细菌和代谢物可以作为DR的新诊断参数,特别是PDR.
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