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Updated: Jun 26, 2025

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
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Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

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菌根CpsA通过cGAS介导的通路激活巨细胞中的I型IFN信号传递

Yue Ding1, Jingfeng Tong1, Geyang Luo1

  • 1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

iScience
|May 20, 2024
PubMed
概括

在感染期间启动I型干扰素 (IFN) 生产时,Mycobacterium结核病蛋白CpsA是必不可少的. 通过影响cGAS-TBK1-IRF3通路和体完整性,CpsA缺乏会损害IFN表达.

关键词:
免疫学 免疫学 免疫学微生物学 微生物学分子微生物学分子微生物学

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