青少年时期的不良坚持是患有基尿症的患者失去随访的危险因素
Marianna Beghini1, Maximilian Pichler1, Fiona Carolina Tinnefeld1
1Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Molecular genetics and metabolism reports
|May 20, 2024
概括
青春期不良的饮食遵守增加了患有基尿症 (PKU) 的成年人失去随访 (LTFU) 的风险. 早期识别和监测这些患者对于维持持续护理至关重要.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 遗传学 是一个遗传学.
- 儿科内分泌学 儿科内分泌学
背景情况:
- 基尿症 (PKU) 管理需要终身坚持严格的饮食计划.
- 成年PKU患者中随访损失 (LTFU) 的高率对长期健康结果构成重大挑战.
- 青春期代表了一个关键的过渡期,在这个时期,治疗的坚持可能会受到影响,这可能会影响成年人护理的连续性.
研究的目的:
- 为了确定与随访丧失 (LTFU) 相关的风险因素,在患有基uria (PKU) 的成年患者中.
- 调查青少年照顾和遵守对PKU成人随访率的具体影响.
- 为了确定青春期饮食不良是否会预测成年后的LTFU.
主要方法:
- 对1993-2019年青少年和成人PKU患者的纵向数据的回顾性分析.
- 定义LTFU是18岁后至少两年的接触中断.
- 多变量考克斯回归分析以评估风险因素,包括性别,青少年的饮食遵守 (氨酸水平),接触频率和成人第一次访问时的年龄.
主要成果:
- 这项研究包括93名患者 (52名男性,41名女性) 被诊断患有经典PKU.
- 58%的患者在成年期经历了跟踪损失 (LTFU).
- 青春期饮食不良与成年期LTFU风险增加显著相关 (p=0.028).
结论:
- 青少年不遵守饮食是成年PKU患者失去随访的重要预测因素.
- 实施针对性监测对于具有不良青少年坚持史的成年PKU患者至关重要.
- 青春期的积极干预对于确保在整个成年期持续参与PKU护理至关重要.
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