在精神分裂症患者的血清克洛托和FGF23水平
Aslı Kazgan Kılıçaslan1, Sevler Yıldız2, Burcu Sırlıer Emir3
1Department of Psychiatry, Bozok University, Yozgat, Turkey.
Psychiatry and clinical psychopharmacology
|May 20, 2024
概括
与健康人相比,精神分裂症患者的克洛托和纤维细胞生长因子23的血清水平较高. 这表明克洛托/纤维细胞生长因子23通路可能参与精神分裂症的发病.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症的发病包括炎症过程.
- 克洛托和纤维细胞生长因子23 (FGF23) 是具有细胞调节和炎症作用的蛋白质.
- 以前的研究还没有广泛探索Klotho,FGF23和精神分裂症之间的关系.
研究的目的:
- 为了比较精神分裂症患者和健康对照者的血清Klotho和FGF23水平.
- 调查精神分裂症患者血清Klotho和FGF23水平之间的相关性.
- 探索Klotho/FGF23通路在精神分裂症中的潜在作用.
主要方法:
- 一项涉及40名男性精神分裂症患者和40名健康男性对照者的病例控制研究.
- 血清克洛托和FGF23水平使用酶相关免疫吸收试验 (ELISA) 进行测量.
- 收集了社会人口统计数据和临床尺度 (PANSS,CGI).
主要成果:
- 与健康对照组相比,精神分裂症患者的血清中Klotho和FGF23的水平显著更高 (P=.048和P=.010).
- 在所有受试者中,血清Klotho和FGF23水平之间发现了强烈的正相关性 (r=0.816;P <.001).
结论:
- 这项研究是第一个报告精神分裂症患者血清克洛托和FGF23水平升高的研究.
- 克洛托/FGF23通路可能与精神分裂症的病理生理学有关.
- 研究Klotho和FGF23在炎症中的作用可能为了解精神分裂症病因和治疗提供新的途径.
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