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持续的睡眠限制和抵抗运动对年轻女性骨肌肉转录的相互作用效应

Olivia E Knowles¹, Megan Soria², Nicholas J Saner³

¹Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.

Physiological genomics

|May 20, 2024

概括

睡眠限制与抵抗运动相结合,在训练有素的女性中显著改变了骨肌肉基因表达. 这种相互作用表明,在睡眠不足的情况下炼可能会阻碍最佳的肌肉适应,而不是在足够的休息下炼.

科学领域:

运动生理学运动生理学
分子生物学分子生物学
睡眠科学睡眠科学

背景情况:

睡眠不足和运动是已知的骨肌肉基因表达的调节者.
睡眠限制和抵抗运动对肌肉转录组的相互作用影响尚不清楚.

研究的目的:

调查9个晚上睡眠限制 (SR) 与反复抵抗运动 (REx) 结合对年轻,训练有素的女性骨肌肉转录组的影响.

主要方法:

采用随机交叉研究设计,对10名健康,受过训练的女性进行了研究.
参与者接受了9个晚上的睡眠限制 (5小时的床上时间) 或正常睡眠 (≥7小时的床上时间).
抵抗运动会在3,5,7和9日进行,在3日和9日进行运动前和后收集的肌肉活检,以进行RNA测序和西部斑分析.

主要成果:

仅仅睡眠限制并没有显著影响肌肉转录组.
经过三次阻力运动,在正常睡眠和睡眠限制条件下,大约有3000个转录在正常睡眠和睡眠限制条件下受到差异调节.
观察到基因调节的显著差异,只有39%的下调和18%的上调基因在两种疾病之间是共同的,这表明睡眠限制对运动反应的缓解作用.

结论:

睡眠限制和抵抗运动相互作用,在年轻,训练有素的女性中修改骨肌肉的转录基因路径.
在睡眠限制的条件下进行阻力运动可能会导致与充足睡眠的运动相比,不同的适应反应.
这些发现凸显了足够睡眠对于优化骨肌肉中运动诱导的适应的重要性.

关键词:

运动就是炼身体.基因基因基因基因失眠失眠失眠失眠失眠转录组 (transcriptome) 是一个转录组.

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