在看似健康的成年人中,COVID-19暴露与自主神经系统功能障碍之间的关联:一项观察性研究
A M Osailan1, M Batarfa, Z Aldosari
1Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia. ahmad.osailan@gmail.com.
概括
暴露于COVID-19与自主神经系统 (ANS) 功能障碍有关,暴露个体的dysautonomia症状较高表明这一点. 这项研究探讨了COVID-19暴露后健康的年轻成年人中的ANS.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 生理学 生理学 生理学
背景情况:
- 由SARS-CoV-2引起的COVID-19可以影响多个器官系统,包括自主神经系统 (ANS).
- 在COVID-19后,报告了ANS功能障碍Dysautonomia,但健康年轻人的研究是有限的.
- 了解COVID-19暴露对这一人口中的ANS功能的影响至关重要.
研究的目的:
- 为了研究自主神经系统 (ANS) 脱自主性和健康年轻成年人中COVID-19暴露之间的关系.
- 为了比较暴露和未暴露于COVID-19的个体之间的ANS功能.
- 为了确定影响COVID-19后dysautonomia严重程度的因素.
主要方法:
- 评估了141名健康参与者 (平均年龄为18-24.5岁,83%是男性).
- 自主神经系统 (ANS) 功能使用复合自主症状量表 (COMPASS-31) 和心率变化 (HRV) 来测量.
- 通过国家健康状况跟踪应用程序 ("Sehhaty", "Twakkalna") 确认了COVID-19暴露.
主要成果:
- 在COMPASS-31得分和COVID-19暴露之间发现了弱反相关性 (r=-0.2,p=0.04).
- 与未接触者 (中位数=12) 相比,暴露于COVID-19的个人报告了显著更高的dysautonomia症状 (中位数=15).
- 在心率变化 (HRV) 和COVID-19暴露之间没有观察到显著的关联. 身高和性别与暴露组的COMPASS-31分数相关.
结论:
- 暴露于COVID-19与自主神经系统 (ANS) 功能较差有关,表现为增加的dysautonomia症状.
- 该研究强调了COVID-19暴露和未暴露的年轻成年人之间自主症状得分的显著差异.
- 身高和性别似乎影响了暴露于COVID-19的个体中dysautonomia的严重程度.
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