基于不同兴趣区域选择方法的Graves眼病病阶段的T2映射的性能
Libin Yang1,2, Xiaomin Dai1,2, Jiawei Su1,2
1Shengli Clinical Medical College of Fujian Medical University, Fujian, Fuzhou, PR China.
Acta radiologica (Stockholm, Sweden : 1987)
|May 20, 2024
概括
T2映射有效地分阶段格雷夫斯眼病 (GO) 活动. 在眼外肌肉 (EOMs) 中的T2放松时间 (T2RT) 测量显示了活性GO的较高值,与疾病严重程度相关,并提供了可靠的成像生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 格雷夫斯眼病 (GO) 的分期对于临床管理至关重要.
- 传统的T2加权成像在准确分阶段上有局限性.
研究的目的:
- 评估T2绘图的有效性,使用两个不同的感兴趣区域 (ROI) 来分阶段 GO活动.
- 为了比较来自不同ROI的T2放松时间 (T2RT) 测量的诊断性能.
主要方法:
- 根据临床活性评分 (CAS) 分类的56名GO患者的追溯分析.
- 测量T2放松时间 (T2RT) 在眼外肌肉 (EOMs) 使用T2映射与两个ROI策略:T2RTROI-1 (所有四个EOM) 和T2RTROI-2 (最炎症的EOM).
- 活跃和非活跃的GO组之间的T2RT值的比较以及与CAS的相关性.
主要成果:
- 在活跃的GO患者中,T2RTROI-1和T2RTROI-2值都显著高 (P < 0.001).
- T2RT值显示出与CAS的正相关性 (rs=0.73,0.69; P <0.001).
- 最佳切割值为T2RTROI-1的0.822和T2RTROI-2的0.827的曲线下的高面积 (AUC),与观察者之间的良好协议 (ICC=0.954和0.882,分别).
结论:
- 这两种ROI方法的T2RT值对于评估GO疾病活性有价值.
- 由于其诊断性能和可重复性,T2RTROI-1被推作为GO分期的理想成像生物标志物.
- T2映射为GO分期提供了一种可靠的定量方法.
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