墙壁厚度对冷热气球除的组织冷却效应的影响
Masaharu Masuda1, Yasuhiro Matsuda1, Hiroyuki Uematsu1
1Kansai Rosai Hospital Cardiovascular Center, 3-1-69 Inabaso, Amagasaki, Hyogo 660-8511, Japan.
概括
结冷气球除的冷却效果随着心肌厚度的增加而减弱. 在肺静脉隔离期间,较深的组织层经历的冷却较少,这表明仔细考虑组织深度对于有效的冷却气球程序至关重要.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 电子生理学 电子生理学
背景情况:
- 了解冷却气球除对心脏组织的热效应对于优化肺静脉隔离程序至关重要.
- 目前关于在肺静脉骨处冷气球冷期间组织冷却的深度的知识是有限的.
研究的目的:
- 为了研究和划分通过冷热气球在肺静脉骨中进行切除而实现的组织冷却的程度.
- 评估心肌厚度的变化如何影响冷却效应在冷却气球应用期间.
主要方法:
- 使用3D打印的左心房肺静脉模型,安装了不同厚度的猪大腿肌肉 (2,4,6毫米).
- 在模拟生理条件下 (37°C水浴,血流模拟) 在模型上的肺静脉骨进行冷.
- 使用放置在冷却气球对面的热电偶监测组织冷却,测量温度变化超过180秒.
主要成果:
- 观察到心肌厚度与组织冷却程度之间存在显著的相关性.
- 180秒的平均温度为-41.4°C (2mm),-33.0°C (4mm) 和8.0°C (6mm),表明冷却减少,厚度增加 (P < 0.0001).
- 温度下降的速度在较薄的组织中也更为,这表明冷却效应更明显,更快.
结论:
- 冰冷气球除的冷却效率与肌肉心脏厚度相反.
- 更深层的心肌组织层受到冷气球冷过程中的冷却的影响较小.
- 对于肺静脉隔离的冷却气球移除的临床应用应考虑心肌厚度的变化,以确保最佳的治疗结果.
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