纳米颗粒破坏人类胎盘分泌的调节,对血管生成和血管化产生影响
Battuja Dugershaw-Kurzer1,2, Jonas Bossart1,2,3, Marija Buljan1,3
1Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland.
概括
怀孕期间接触纳米颗粒 (NP) 会破坏胎盘分泌物,影响血管发育. 这项研究强调了与工程和环境NP相关的风险,强调了安全评估的必要性.
科学领域:
- 环境健康 环境健康
- 发育毒理学 发展毒理学
- 纳米技术安全 纳米技术安全
背景情况:
- 怀孕期间纳米粒子 (NP) 暴露与不良的胚胎和胎儿结局有关.
- 对NP发育性毒性的机制,特别是对胎盘的影响,仍然在很大程度上是未知的.
- 胎盘分泌物对策划妊娠成功至关重要.
研究的目的:
- 研究工程 (二氧化,二氧化) 和环境 (柴油废气颗粒) 的NP对人类胎盘分泌物的影响.
- 通过胎盘分泌体分析来确定NP的发育毒性机制.
- 评估NP改变的胎盘分泌物对血管和神经发育过程的影响.
主要方法:
- 暴露人类胎盘扩张物各种NP的生理相关度.
- 在条件介质 (CM) 中使用秘密学分析分泌因子和细胞外囊泡 (EV) 相关的蛋白质.
- 在体外对CM对血管生成,血管生成和早期神经发育过程的影响的评估.
主要成果:
- 单次NP暴露导致胎盘信号的物质和妊娠阶段特定的放松调节.
- 许多炎症,血管和内分泌因素,以及与EV相关的蛋白质都发生了变化.
- 无NP条件介质诱导了显著的抗血管原和抗血管原作用.
- 早期的神经发育过程只受到NP暴露的CM的边际影响.
结论:
- 工程和环境NP可以广泛干扰胎盘分泌物.
- 血管形态发生是间接NP发育毒性的敏感指标.
- 整体分泌学方法对于评估怀孕期间的NP安全性至关重要.
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