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Updated: Jun 26, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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TCF12通过转录激活SPHK1,通过促进S1P/S1PR4/STAT3轴来诱导骨肉瘤血管生成

Wo Li1, Jitong Liu1, Ting Cai1

  • 1Department of Anesthesiology, Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University), Changsha, Hunan Province, China.

Molecular and cellular biology
|May 20, 2024
PubMed
概括

转录因子12 (TCF12) 通过激活氨酸激酶1 (SPHK1) 和促进血管生成,驱动骨肉瘤恶性病变. 准TCF12可能为骨髓瘤提供新的治疗策略.

关键词:
骨质肉瘤骨质肉瘤是什么在S1P中,它是S1P.在 S1PR4/STAT3 信号通道中.这就是SPHK1的原因.在TCF12中,我们可以使用TCF12.血管新生是因为血管新生.

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