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2型糖尿病肠道菌组的变化与不同人群的甲福明治疗有关
Emily Van Syoc1,2,3, Michelle Pistner Nixon4, Justin D Silverman3,4,5,6
1Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, USA.
mBio
|May 20, 2024
概括
2型糖尿病 (T2D) 和甲胺改变了肠道真菌微生物群. 甲胺是一种常见的糖尿病药物,可以混研究肠道菌群和T2D的研究,影响人类和小鼠的真菌组成.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 药理学 药理学是指药理学的学科.
背景情况:
- 人的肠道微生物组包括细菌和真菌,在代谢性疾病中研究不足的真菌群体 (mycobiome).
- 2型糖尿病 (T2D) 与肠道微生物组的改变有关,但菌组的作用及其对甲胺等治疗的反应尚不清楚.
研究的目的:
- 为了研究T2D和甲胺对人类肠道菌群的影响.
- 区分T2D与甲福林治疗对真菌群落的影响.
- 确定甲胺作为T2D-mycobiome研究中的潜在混因素.
主要方法:
- 对一个大型多国人类肠道菌群组队列 (1000个样本) 的分析.
- 在小鼠实验模型中的验证与甲福明的管理.
- 应用贝叶斯的多项物流正常模型来评估真菌的丰度转移.
主要成果:
- 两种T2D和甲福林治疗都与肠道真菌相对丰富度的明显变化有关.
- T2D与Saccharomycetes和Sordariomycetes类的变化相关. T2D与Saccharomycetes和Sordariomycetes类的变化相关.
- 在人类和小鼠中,甲胺治疗始终与*Fusarium*和*Tetrapisipora*属有关.
结论:
- 甲胺和T2D诱导肠道菌群中微妙但显著和明显的变化.
- 甲福明可以混肠道真菌和T2D之间的关联.
- 未来对代谢疾病和肠道微生物的研究必须考虑药物干预措施,如甲胺.
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