临床特征和由多药耐药生物体引起的热性肝的危险因素:一项回顾性研究
Qin Long1,2, Xiaoyu Zhao1,3, Chang Chen2
1Institute of Antibiotics, Huashan Hospital Fudan University, Shanghai, China.
Virulence
|May 20, 2024
概括
多种耐药性细菌越来越多地导致肝炎性. 风险因素包括并发症,最近的手术和成像气体,有助于早期识别和个性化治疗,以获得更好的结果.
科学领域:
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 发烧性肝 (PLA) 的发生率正在上升,特别是由于多药耐药生物体 (MDROs).
- 了解MDRO-PLA的临床特征和风险因素对于有效管理至关重要.
研究的目的:
- 为了确定与多药耐药细菌引起的发烧性肝相关的临床特征和危险因素.
- 开发一种用于早期识别高风险患者的预测工具.
主要方法:
- 对239名PLA患者的回顾性分析.
- 多变量后勤回归用于识别MDRO感染的风险因素.
- 开发和验证一个预测名ogram.
主要成果:
- 在PLA病例中,MDRO占23.0%,多微生物感染率为14.6%.
- MDRO-PLA与较高的死亡率 (15.9%与2.3%) 和多微生物感染有关.
- MDRO-PLA的独立风险因素包括查尔森并发症指数,最近住院/手术,以及成像中的气体.
- 开发的名图表显示出高的诊断准确性 (灵敏度为0.940,特异性为0.878).
结论:
- 导致PLA的MDROs表现出不同的临床特征和危险因素.
- 早期识别高风险患者使用名图可以改善PLA管理和个性化治疗策略.
相关概念视频
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Pleural Effusion II: Symptoms and Management
165
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
165
Diseases of the Liver and Gallbladder
519
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
519
Inflammatory Bowel Disease I: Ulcerative Colitis
165
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
165
Factors Influencing Drug Absorption: Disease States and Pharmacology
497
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
497
Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K


