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显而易见的扩散系数和组织刚性与肝细胞癌的不同瘤微环境特征有关

Jie Chen^1,2, Zhenru Wu³, Zhen Zhang^1,2

¹Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, China.

European radiology

|May 20, 2024

概括

肝细胞癌 (HCC) 的明显扩散系数 (ADC) 反映了细胞性,而瘤硬度与瘤-肌瘤比率相关. 周围瘤硬度可能表明瘤内免疫微环境,有助于免疫疗法选择.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
病理学病理学病理学

背景情况:

肝细胞癌 (HCC) 是一种复杂的恶性瘤.
了解瘤微环境 (TME) 对有效的治疗策略至关重要.
需要非侵入性成像生物标志物来评估TME特征.

研究的目的:

调查组织扩散,硬度和HCC中TME特征之间的关联.
为了确定成像生物标志物是否可以反映HCC.的基因病理特征.
探索成像在指导免疫疗法选择中的潜力.

主要方法:

预期包括72名接受手术前MRI (扩散加权成像和弹性图像) 的患者.
测量瘤和周围瘤区域的明显扩散系数 (ADC) 和硬度.
在切除的瘤中估计细胞密度,瘤-肌瘤比率 (TSR) 和CD8+T细胞透率.

主要成果:

瘤ADC和瘤硬性之间没有发现相关性.
瘤细胞密度与瘤ADC有关.
瘤-肌瘤比率与瘤硬性有关.
瘤内CD8+T细胞透与瘤周围硬性有关,不依纤维化阶段和年龄.

结论:

瘤ADC是细胞性的一个更好的生物标志物,而不是HCC中的瘤硬度.
瘤硬度反映了瘤-肌瘤比率,可以作为瘤内免疫微环境的成像生物标志物.
周围瘤硬性显示出作为HCC免疫透的成像生物标志物的潜力,有助于免疫治疗患者的选择.

关键词:

癌瘤的癌症是什么细胞密度细胞密度扩散磁共振成像技术的研究.磁共振弹性图形学磁共振弹性图形学瘤微环境是一个微环境.肝细胞细胞肝细胞细胞

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