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关于T2D基础胰岛素治疗的开放问题:德尔菲共识
, Raffaella Buzzetti1, Riccardo Candido2
1Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Acta diabetologica
|May 20, 2024
概括
基础胰岛素 (BI) 对于2型糖尿病 (T2D) 管理至关重要. 专家建议立即启动和定位BI,最好作为附加疗法,第二代类型提供优势.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2D) 治疗正在发展,需要重新评估基础胰岛素 (BI) 治疗的作用.
- 许多临床问题围绕着BI的使用,促使专家达成一致的实际指导.
研究的目的:
- 为医生提供基本胰岛素 (BI) 治疗2型糖尿病 (T2D) 的实用指导,使用德尔菲共识方法.
- 解决有关BI在T2D管理中的定位和优化的开放问题.
主要方法:
- 一个由6名专家组成的小组开发了29个关于BI治疗的陈述,包括强化,减强和第二代类似物 (2BI).
- 一个由31名糖尿病专家组成的小组通过专门的网站使用9分级别来评价陈述的相关性.
- 使用RAND/UCLA适当性方法来评估专家的分歧.
主要成果:
- 所有29个陈述都达到了专家一致意见;26个被认为是相关的.
- 新的药物类别可能允许延迟BI启动和简化治疗.
- 迅速启动和定位BI是必不可少的;它应该添加到,而不是取代心保护疗法.
- 第二代基底胰岛素 (2BI) 是由于其药理特征和易于使用而被优先选择的.
结论:
- 基础胰岛素 (BI) 治疗仍然是管理2型糖尿病 (T2D) 患者的重要组成部分.
- 专家共识为优化BI在不断变化的T2D治疗环境中的使用提供了实际指导.
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