胰岛素抵抗与多发性硬化症之间的关联:系统性审查和元分析
Mahdi Sepidarkish1, Narges Kalantari2,3, Tahmineh Gorgani-Firouzjaee3
1Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
Metabolic brain disease
|May 20, 2024
概括
这项研究发现,在多发性硬化症 (MS) 患者中,胰岛素抵抗和胰岛素水平之间存在显著联系. 这些代谢变化在混合多发性硬化症患者组中更为明显,这表明存在复杂的关系.
科学领域:
- 神经免疫学 神经免疫学
- 代谢障碍 代谢障碍 代谢障碍
- 系统审查是系统的审查.
背景情况:
- 代谢干扰在多发性硬化症 (MS) 中越来越多地被认可.
- 胰岛素在神经疾病中的作用是有争议的,需要进一步研究.
- 了解胰岛素-MS连接对于潜在的治疗点至关重要.
研究的目的:
- 系统地审查和元分析胰岛素抵抗 (IR) 和多发性硬化之间的关联.
- 探索胰岛素水平和MS之间的关系.
- 使用现有数据量化这些协会的实力.
主要方法:
- 观察性研究的系统审查和元分析.
- 在Medline,Scopus和Web of Science数据库中搜索到2023年5月26日.
- 使用随机效应模型与REML估计器进行IR (HOMA-IR) 和胰岛素水平的元分析.
主要成果:
- 包括18个数据集 (2012-2022);在IR,胰岛素和MS之间发现了显著的关联.
- 标准化平均差异 (SMD) 的IR和胰岛素分别为0.78和0.72.
- 与仅RRMS (SMD:0.59) 相比,在混合MS类型的研究中观察到更强大的效果大小 (SMD:1.09).
结论:
- 胰岛素抵抗,胰岛素水平和多发性硬化症之间存在显著的关联.
- 在包括多样化的多发性硬化患者群体在内的研究中,这种关联似乎更为强烈.
- 报告指出异质性很高,强调需要进一步研究来证实这些发现.
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