母亲尿液化物和36个月的儿童神经行为
Ashley J Malin1,2, Sandrah P Eckel3, Howard Hu3
1Department of Epidemiology, College of Public Health and Health Professions University of Florida, Gainesville.
JAMA network open
|May 20, 2024
概括
在美国人口中,高产前化物暴露与儿童的神经行为问题增加有关. 这项研究突出了潜在的风险,并表明需要产前化物暴露指南.
科学领域:
- 环境健康 环境健康
- 神经发育儿科 神经发育儿科
- 毒理学 毒理学 毒理学
背景情况:
- 以前的研究表明,在加拿大和墨西哥人群中,产前化物暴露与神经行为缺陷之间存在联系.
- 在美国人口中,产前化物暴露与神经行为结果之间的关联仍未得到检查.
研究的目的:
- 为了研究第三个月的母亲尿液化物 (MUF) 水平与3岁儿童神经行为结果之间的关联,在美国的队列中.
- 为了确定产前化物暴露是否与美国幼儿神经行为问题的风险增加有关.
主要方法:
- 采用前性队列研究设计,利用存档的尿样和来自加利福尼亚州洛杉矶MADRES怀孕队列的神经行为数据.
- 作为产前暴露的生物标志物,测量了母亲的尿化物 (MUF),并使用学前儿童行为检查清单 (CBCL) 评估了儿童的神经行为.
- 线性和后勤回归模型被用于分析特定重力调整的MUF (MUFSG) 和CBCL复合分数 (总问题,内部化,外部化) 之间的关联.
主要成果:
- 总共有229对母婴对被纳入分析.
- 母亲尿液化物水平的增加 (每增加1次IQR) 与儿童在边界或临床范围内 (OR,1.83;P=.008) 具有Total Problems T分数的几率几乎翻倍显著相关.
- 更高的产前化物暴露也与内化问题 (B=2.29;P=.01) 和总问题 (B=2.14;P=.02) 的T分数显著增加有关.
结论:
- 产前化物暴露与美国人口中儿童的神经行为问题增加有关.
- 这些发现强调了在关键发育时期化物暴露的潜在不良影响.
- 该研究表明,可能需要修订有关怀孕期间化物暴露限值的建议.
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