75岁以上接受电治疗的抑郁老年人的自杀行为和全因死亡率:瑞典基于登记的比较研究
Khedidja Hedna1,2,3, Mattias Jonson1,2,4, Robert Sigström1,2,5
1Department of Psychiatry and Neurochemistry, AgeCap Center, Gothenburg University, Gothenburg, Sweden.
International journal of geriatric psychiatry
|May 20, 2024
概括
电疗法 (ECT) 在75岁以上的老年人中没有增加自杀行为风险. 这种治疗与抑郁症老年患者全因死亡率降低有关.
科学领域:
- 老年精神病学是一门精神病学专业.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 晚年抑郁症带来重大风险,包括自杀行为和死亡率.
- 电疗法 (ECT) 是对老年人严重抑郁症的公认有效治疗方法.
- 关于ECT在老年人中关于自杀行为和死亡率的具体结果的研究有限.
研究的目的:
- 调查ECT与75岁及以上中度至重度抑郁症成年人的自杀行为 (致命和非致命) 之间的关联.
- 为了比较使用ECT治疗的老年住院患者与接受其他抑郁症治疗的老年住院患者之间的全因死亡率.
- 解决关于ECT在老年人口中安全性和有效性的研究缺口.
主要方法:
- 对于在2011年至2017年期间被诊断患有中度至重度抑郁症的75岁以上住院患者进行了回顾性队列研究.
- 使用精确和倾向分数匹配来创建可比的ECT接受者和接受其他抑郁症治疗的人群.
- 治疗开始后3个月内和4个月至1年内自杀行为和所有原因死亡率的比较率.
主要成果:
- 1802名ECT接受者与4457名接受其他治疗的患者进行了匹配.
- 在ECT和其他治疗方法之间,没有发现自杀行为风险的显著差异 (3个月 aOR 0.73; 1年 aOR 1.34).
- 与其他治疗相比,ECT组的全因死亡率明显较低 (3个月的aOR为0.35;1年的aOR为0.65).
结论:
- 在75岁及以上的患者中,电疗法 (ECT) 与自杀行为风险的增加无关.
- 在这个老年人群中,使用ECT证明了全因死亡率的降低.
- 虽然结果表明潜在的益处,但由于研究的观察性质,建议在推断因果关系时谨慎行事.
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