非热大气等离子体在抗瘤中的机制:影响细胞内RONS和调节信号通路
Wenjie Wang1,2, Peijia Zheng1,2, Liang Yan1,2
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Free radical research
|May 20, 2024
概括
非热大气等离子体 (NTAP) 通过诱导细胞死亡和抑制生长,有效地对抗瘤. 本综述阐明了NTAP如何产生反应性氧和物种 (RONS) 来触发抗瘤途径.
科学领域:
- 生物医学工程 生物医学工程
- 等离子体物理学的物理学
- 癌症研究 癌症研究
背景情况:
- 非热大气等离子体 (NTAP) 具有显著的抗瘤特性,包括抑制增殖和转移,并促进亡.
- 反应性氧物种 (ROS) 和反应性物种 (RNS) 被认为是NTAP的关键效应成分,但它们的精确抗瘤机制需要系统的阐明.
研究的目的:
- 系统地总结NTAP抗瘤作用背后的机制.
- 阐明NTAP如何影响细胞内反应性氧和物种 (RONS) 度.
- 详细说明RONS诱导的关键信号通路 (NRF2,PI3K,MAPK,NF-κB) 的失调及其与抗瘤结果的联系.
主要方法:
- 文献综述和对NTAP和癌症现有研究的综合.
- 对NTAP诱导的RONS生成机制的分析.
- 检查瘤细胞中RONS介导的信号通路改变.
主要成果:
- 通过直接和间接的机制,NTAP治疗导致细胞内RONS度增加.
- 升高的RONS会破坏关键细胞通路的调节,包括NRF2,PI3K,MAPK和NF-κB.
- 这些途径的失调与观察到的抗瘤效应相关,如减少扩散,转移和增强亡.
结论:
- 对NTAP的抗瘤机制的全面理解包括RONS生成和随后的途径调制.
- 这份系统摘要为推进NTAP研究及其在瘤学中的临床转化提供了基础.
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