红细胞分布宽度和高血压之间的关联:来自NHANES 1999-2018年的结果
Ying Chen1, Xiaoxiao Hou2, Jiaxin Zhong3
1Medical Laboratory Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, China.
PloS one
|May 20, 2024
概括
红细胞分布宽度 (RDW) 与美国成年人的高血压有关. 观察到一个反向的J形关系,表明较高的RDW水平与高血压风险增加相关.
科学领域:
- 心血管疾病流行病学
- 血液学 血液学 血液学
背景情况:
- 高血压是全球主要的健康问题.
- 红细胞分布宽度 (RDW) 和高血压之间的联系在美国的大型成年人群中尚未得到充分证实.
研究的目的:
- 调查RDW与美国成年人高血压患病率之间的关联.
- 探索这种关系的性质,使用大型,全国代表性的数据集.
主要方法:
- 利用了1999-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 从完整血清数据分析红细胞分布宽度 (RDW).
- 通过问卷和血压测量评估高血压.
- 采用多变量加权后勤回归,子组和平滑曲线分析.
主要成果:
- 与非高血压患者相比,高血压患者的RDW值显著更高 (P <0.001).
- 在对共变量进行调整后 (OR:1.17,P <0.001) 确认了RDW和高血压患病率之间的正相关性.
- 在最高的RDW四分位数中的参与者表现出最大的高血压风险 (OR:1.86,P <0.001).
- 确定了RDW和高血压之间的反向J形关系,转折点为12.93%.
结论:
- 这项研究为美国成年人RDW和高血压之间的关联提供了新的见解.
- 发现了RDW和高血压患病率之间的反向J形关系.
- 这些发现为高血压预防和管理策略提供了潜在的新途径.
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