Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.1K
Circuit Terminology01:14

Circuit Terminology

638
An electrical network is a system composed of interconnected elements, such as resistors, capacitors, inductors, and voltage or current sources. Unlike a circuit, an electrical network does not necessarily form a closed path. In other words, while all circuits can be considered networks due to their interconnected nature, not every network qualifies as a circuit.
A circuit, on the other hand, is also an interconnected system of electrical elements but must contain one or more closed paths.
638
Network Function of a Circuit01:25

Network Function of a Circuit

281
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
281
Electrical Synapses01:28

Electrical Synapses

8.3K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
8.3K
Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Proteome remodeling in the zoospore-to-vegetative cell transition of the stramenopile Aurantiochytrium limacinum reveals candidate ectoplasmic network proteins.

PloS one·2025
Same author

Horizontal Gene Transfer and Fusion Spread Carotenogenesis Among Diverse Heterotrophic Protists.

Genome biology and evolution·2023
Same author

Rapid evolutionary changes in gene expression in response to climate fluctuations.

Molecular ecology·2020
Same author

The impact of different agroecological conditions on the nutritional composition of quinoa seeds.

PeerJ·2018

相关实验视频

Updated: Jun 25, 2025

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.8K

在分子网络中,近距离节点之间的电线比远距离节点之间的电线更快地发展.

Alejandro Gil-Gomez1, Joshua S Rest1

  • 1Department of Ecology and Evolution, Laufer Center for Physical and Quantitative Biology, Stony Brook University, 650 Life Sciences, Stony Brook, NY 11794-4254, USA.

Molecular biology and evolution
|May 20, 2024
PubMed
概括

药物相互作用 (DDI) 在物种之间迅速发生变化,为估计分子网络演变提供了一种新的方式. 协同DDI涉及更快进化的密切联系的目标,为进化速度提供了洞察力.

科学领域:

  • 进化生物学是进化的生物学.
  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 分子网络,包括蛋白质与蛋白质相互作用 (PPI) 和代谢网络,随着物种分离而变化.
  • 由于有限的数据和模型生物的偏见,研究跨物种的网络进化是具有挑战性的.
  • 药物相互作用 (DDI) 可以作为分子网络拓变化的代理.

研究的目的:

  • 提出和评估跨物种DDI变化率作为分子网络演变的估计.
  • 研究协同DDI与其分子点的进化速率之间的关系.
  • 探索药物组合 (DC) 数据对大规模网络演变研究的有用性.

主要方法:

  • 计算了DDI的进化速率,使用了高吞吐量细菌的高吞吐量数据.
  • 应用了遗传学比较方法来分析DDI在进化时间上的差异.
  • 在PPI和协同功能网络中映射药物目标,以分析协同DDI及其演变速率.

主要成果:

  • 在较短的进化时期,DDI表现出快速分歧,在较长的时间尺度上和.
  • 协同DDI涉及到在网络中进化更接近的分子目标.
  • 在分子网络中更紧密的节点显示出更快的进化速率.
关键词:
生物网络的演化 生物网络的演化药物 药物相互作用格拉姆阴性细菌是一种细菌.遗传学上的比较方法.

更多相关视频

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.1K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.1K

相关实验视频

Last Updated: Jun 25, 2025

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.8K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.1K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.1K

结论:

  • DDI演变的速度可以有效地估计底层分子网络变化的速度.
  • 协同药物相互作用突出了快速演变的分子标.
  • 药物组合数据提供了一个可扩展的方法来研究跨不同物种的网络演变.