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瘤微环境在乳头甲状腺小瘤结节转移中的作用

Mijin Kim^1,2, Chae Hwa Kwon², Bo Hyun Kim^1,2

¹Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea.

Endocrine-related cancer

|May 20, 2024

概括

这项研究确定了与攻击性特征和转移相关的乳头甲状腺微癌 (PTMC) 中的新基因标记物. 这些发现改善了横向淋巴结转移 (LLNM) 和患者预后的预测.

科学领域:

分子瘤学分子瘤学
基因组学就是基因组学.
癌症生物学癌症生物学

背景情况:

目前的遗传标记不足以预测皮肤状甲状腺微癌 (PTMCs) 中的攻击性特征.
侧侧淋巴结转移 (LLNM) 是PTMC预后和治疗策略的一个关键因素.

研究的目的:

在PTMC患者中识别与LLNM (N1b疾病) 相关的新型候选基因标记物.
在PTMC中分析瘤微环境 (TME) 具有和没有LLNM.
探索癌症相关纤维细胞和上皮细胞在PTMC进展和转移中的作用.

主要方法:

使用RNA测序对26个匹配的PTMC瘤和正常甲状腺组织样本进行转录组分析 (N0与N1b).
不同基因表达 (DEG) 分析和功能丰富分析.
瘤微环境 (TME) 特性和特定细胞标记基因的识别的EcoTyper工具.

主要成果:

鉴定了N1b和N0PTMC之间的631个差异表达基因 (DEG),与与瘤发生,粘附,迁移和入侵相关的高调基因.
DEGs在包括异常性肺纤维化,TME,伤口愈合和矩阵金属蛋白酶抑制在内的途径中得到丰富.
N1b PTMCs表现出一种独特的TME,其特征是丰富的纤维细胞和上皮细胞,其中POSTN,FN1 (纤维细胞标记物) 和NOX4,TNC (上皮标记物) 被确定为LLNM预测和复发的有希望的生物标记物.

结论:

特定的纤维细胞和上皮细胞标记基因与PTMC中的LLNM有关.
这些已识别的生物标志物 (POSTN,FN1,NOX4,TNC) 显示出预测LLNM发展和复发的潜力.
该研究提供了有关癌症相关纤维细胞和上皮细胞对PTMC进展和转移的贡献的见解,有助于预后评估.

关键词:

与癌症相关的纤维细胞细胞.侧侧淋巴结转移的发生.甲状腺小瘤是甲状腺小瘤.转录组分析转录组分析瘤微环境是一个微环境.

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