全球纵向活性菌株能量密度 (GLASED):在基于社区的队列队列中,这是一个强大的预后标记
Nay Aung1,2, David H MacIver3,4, Henggui Zhang3
1William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.
European heart journal. Cardiovascular Imaging
|May 20, 2024
概括
全球纵向活性菌株密度 (GLASED) 与传统标志物相比,显示出对死亡率和心血管事件的优异预测. 这种新的成像指标为患者提供了更好的预后评估.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 机器学习 机器学习
背景情况:
- 最佳管理需要准确预测死亡率和不良心血管事件.
- 传统的左心室 (LV) 标志物,如喷射分数,在预后价值上有局限性.
- 为了准确的风险分层,需要新的成像生物标志物.
研究的目的:
- 为了比较23个LV结构和收缩功能标志物的预后效用.
- 确定最佳的成像方法来预测全因死亡率,心血管事件和心力衰竭.
- 为了评估一种新型标志物,全球纵向活性菌株密度 (GLASED).
主要方法:
- 分析了44957名英国生物库参与者的心血管磁共振成像数据.
- 利用机器学习算法提取LV预后标记.
- 将23个潜在的LV标记与未来不良事件风险进行了比较.
主要成果:
- 大多数LV标记物,包括喷射分数,表现出有限的预后能力.
- 玻璃显示出与所有原因死亡率和主要不良心血管事件的显著关联.
- 玻璃表现出最大的危险比率和差异化风险在所有三地动物.
结论:
- 玻璃是所有原因死亡率和主要心血管不良事件的优越预测因素.
- 该研究建议GLASED用于增强患者预后评估.
- 玻璃提供了比传统的成像标记器更好的风险分层.
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