纤维素纤维增强了血静复合医疗密封剂的功能
Efrat Gilboa1, Inbar Eshkol-Yogev2, Shir Giladi1
1Department of Materials Science and Engineering, Tel-Aviv University, Tel-Aviv, Israel.
Journal of biomaterials applications
|May 20, 2024
概括
这项研究开发了一种新的双重微复合材料水凝,使用凝,酸盐,高和纤维素纤维. 增强的水凝显示出更好的机械强度和密封能力,使其适合医疗应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 传统的伤口关闭方法面临着局限性.
- 现有的组织粘合剂和密封剂在生物相容性和机械强度之间的平衡中扎.
- 开发先进的水凝对于改善医疗密封应用至关重要.
研究的目的:
- 为了研究一种新的凝-酸水凝系统用于伤口密封.
- 使用高和纤维素纤维增强机械强度和静血性质.
- 评估配方参数对水凝性能和生物相容性的影响.
主要方法:
- 制造凝-酸盐水凝与碳胺交叉连接.
- 加入高 (血液静止剂) 和纤维素纤维作为功能填充剂.
- 机械性质 (拉伸强度,扬模),密封性,物理性质 (粘度,凝时间,胀),微观结构和生物相容性 (细胞毒性测试) 的表征.
主要成果:
- 双重微型复合材料结构表现出均的填充剂分散和强大的矩阵粘附.
- 观察到密封能力 (247%),抗拉强度 (400%) 和模量 (437%) 的显著协同增强.
- 纤维素纤维主要有助于机械增强,而高则在不影响物理性质的情况下提供血静.
- 细胞毒性测试证实了所有配方的高细胞活力.
结论:
- 开发的双重微复合材料水凝显示出卓越的机械和密封性能.
- 这些水凝为需要快速有效密封的医疗密封应用提供了有前途的解决方案.
- 该配方允许量身定制的特性,使其能够针对各种医疗需求进行优化.
更多相关视频
08:40TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
14.2K
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.8K
相关概念视频
Cellulose and Pectic Polysaccharides
3.5K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
3.5K
Introduction to Hemostasis
7.3K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.3K
Glycosaminoglycans
4.8K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.8K
The Extracellular Matrix
82.3K
Overview
82.3K
Clot Retraction and Fibrinolysis
5.5K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.5K
Fibril-associated Collagen
2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
