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Updated: Jun 25, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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将计算流体动力学建模与机械辅助循环中设备诱导的血小板缺陷联系起来

Jiafeng Zhang1, Dong Han1, Zengsheng Chen1

  • 1From the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

ASAIO journal (American Society for Artificial Internal Organs : 1992)
|May 20, 2024
PubMed
概括

计算流体动力学 (CFD) 建模将血流量与血小板缺陷联系起来. 75Pa的剪切应力值有效预测了机械循环支中的装置诱导的血小板功能障碍.

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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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