胎盘人类乳头瘤病毒感染和不良妊娠结果
Magdalena R Værnesbranden1, Anne Cathrine Staff2, Johanna Wiik3
1Department of Obstetrics and Gynecology, Østfold Hospital Trust, Kalnes, Norway; University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway.
Placenta
|May 20, 2024
概括
胎盘人类乳头瘤病毒 (HPV) 在3%的分娩中被发现. 怀孕中期尿液中的高HPV病毒载荷增加了胎盘HPV风险,但没有任何不良妊娠结果与胎盘HPV有关.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病毒瘤学 病毒瘤学
背景情况:
- 关于人类乳头瘤病毒 (HPV) 在第三季度胎盘中流行率的知识有限.
- 胎盘HPV与不良妊娠结果之间的关联需要进一步调查.
研究的目的:
- 为了确定胎盘HPV在分娩时的患病率.
- 探索与胎盘HPV相关的尿液HPV特征.
- 评估胎盘HPV是否会增加不良妊娠结果的风险.
主要方法:
- 在母婴队列研究中招募孕妇.
- 人类乳头瘤病毒 (HPV) 在胎盘活检和怀孕/分娩尿样上的基因定型.
- 使用回归模型分析母亲特征和不良妊娠结果.
主要成果:
- 胎盘HPV患病率为3% (18/587);怀孕期中期尿液HPV患病率为38% (214/556).
- 中产期高风险 (HR) -HPV和高病毒载量与胎盘HPV有关.
- 只有0.4%的胎盘HPV妇女观察到不良妊娠结果,没有显示增加的风险.
结论:
- 在这个队列中,胎盘HPV的患病率为3%,孕期中期尿道HPV为38%.
- 高的HPV病毒载量是胎盘HPV感染的危险因素.
- 胎盘HPV没有增加妊娠不良结果的风险.
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