柴油颗粒物物质透到正常人体皮肤中,并使用局部胺配方进行干预
Kyong-Oh Shin1,2, Kenya Ishida3, Hisashi Mihara3
1Department of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea.
Skin pharmacology and physiology
|May 20, 2024
概括
柴油颗粒物 (DPM) 含有有毒的多环芳 (PAH),可以穿透皮肤. 一种专门的局部配方有效地阻断DPM和PAH的皮肤透,甚至保护健康的皮肤.
科学领域:
- 皮肤病学 皮肤病学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 柴油颗粒物 (DPM) 是一个重要的空气污染物,携带有毒的多环芳 (PAHs).
- 皮肤暴露于DPM与各种皮肤病和过早衰老有关.
- 皮肤的表皮屏障通常限制DPM的透,但其对吸附毒素的有效性尚未完全理解.
研究的目的:
- 为了研究DPM吸附的PAHs在人体皮肤中的透.
- 评估局部配方在防止DPM和PAH穿透皮肤方面的疗效.
主要方法:
- 使用了暴露于DPM的活体器官培养人体皮肤.
- 在皮肤层中使用液态染色学-并列质谱学量化的特定PAHs (2-甲基甲烯,三烯,甲).
- 评估了局部配方对PAH透的影响.
主要成果:
- 在人类皮肤的表皮和皮肤中检测到吸附于DPM的PAH.
- 与皮肤相比,上皮的PAH水平显著更高.
- 一种形成均膜结构的局部配方明显减少了PAH透到皮肤.
结论:
- 通过DPM吸附的有毒化合物可以穿透完整的皮肤,造成风险.
- 皮肤屏障受损的个体 (例如,亚托皮炎,牛皮) 更容易受到DPM相关的损伤.
- 针对性的局部配方可以创建一个防护屏障,防止DPM和吸附毒素.
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