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Updated: Jun 25, 2025

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
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在人体生殖线上进行表观遗传重编程的体外复制

Yusuke Murase1,2, Ryuta Yokogawa1,2, Yukihiro Yabuta1,2

  • 1Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.

Nature
|May 20, 2024
PubMed
概括

科学家成功地将人类干细胞编程为早期的生殖细胞,为体外生殖和生殖医学的进步铺平了道路.

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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