在现场凝系统用于眼部药物输送
Bakr Ahmed1, Srishty Jaiswal1, Srishti Naryal1
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
概括
在位凝系统通过延长药物存在和提高生物可用性来增强眼部药物输送. 这些先进的配方提供了更好的患者遵守和减少副作用.
科学领域:
- 眼科医生 眼科 眼科
- 药品制造 药品制造 药品制造
- 生物材料是一种生物材料.
背景情况:
- 眼部药物输送面临着诸如生物可用性差和角膜屏障透等挑战.
- 传统的眼睛配方往往需要频繁的管理,导致合规问题和副作用.
研究的目的:
- 系统地审查用于眼部药物输送的现场凝系统的研究.
- 评估这些系统在优化药物释放和治疗结果方面的潜力.
主要方法:
- 2015-2023年出版物和专利的系统文献搜索.
- 包括26篇研究论文和14项符合特定标准的专利.
主要成果:
- 在现场凝系统可以延长活性药物成分 (API) 在眼睛中的停留时间.
- 这导致持续的药物释放,改善眼部生物可用性和减少全身吸收.
- 系统提供眼睛表面屏障,可能降低感染和炎症风险.
结论:
- 在现场凝系统提供了一个有希望的,低复杂性的方法,以提高眼部药物输送.
- 这些系统改善了患者的服药性,并减少了剂量频率和副作用.
- 需要进一步的研究和开发才能充分发挥其治疗潜力.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338
01:09Methods for Studying Drug Absorption: In situ
227
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
227