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Updated: Jun 25, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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扩大CAR-T疗法的可用目标,以克服基于"进化陷"的瘤耐药性

Xu Wang1, Pu Wang1, Ying Liao1

  • 1Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China.

Pharmacological research
|May 20, 2024
PubMed
概括

使用"进化陷"概念在耐药瘤中准必需基因显示出有希望. PDPN CAR-T细胞有效地消除了耐药细胞,这表明克服瘤耐药性的新策略.

关键词:
卡特-T疗法是一种治疗方法.癌症,耐药性 癌症,耐药性进化陷是一个进化陷.拉帕提尼布 (PubChem CID: 208908) 的使用情况在PDPN中使用PDPN.

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