针对C反应蛋白的四种商业可用的点照顾设备的分析性能和用户友好性
Lieve Van Hoovels1, Bo Massa2, Anne Stavelin3
1Department of Laboratory Medicine, OLV Hospital Aalst, Aalst, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
概括
对C-反应蛋白 (CRP) 的治疗点检测 (POCT) 有助于抗生素管理. 四种POCT-CRP测定的分析性能和用户友好性各不相同,突出了中央实验室质量保证的需要.
科学领域:
- 临床化学 临床化学
- 照顾点检测检测 照顾点检测
- 抗微生物药物管理委员会
背景情况:
- 在初级保健中,对C反应蛋白 (CRP) 的点照顾测试 (POCT) 可以减少不必要的抗生素处方.
- 这对于打击抗微生物药物耐药性的上升至关重要.
研究的目的:
- 评估四种不同的POCT-CRP试验的分析性能和用户友好性.
- 评估的试验包括QuikRead go easy,LumiraDx,cobas b 101和Afinion 2等.
主要方法:
- 使用血池和对照材料评估不准确性.
- 对ERM-DA474/IFCC进行了真实验证,并与使用血和毛细血管全血样本的中央实验室方法 (cobas c 503) 进行了比较.
- 用户友好性通过问卷进行评估.
主要成果:
- 日间不准确率在4.5%至11.5%之间.
- 科巴斯b101和阿菲尼奥2测定结果与中央实验室方法达成最佳一致.
- 在用户友好性方面,Afinion 2得分最高,而LumiraDx没有达到性能标准.
结论:
- 在可用的POCT-CRP设备的分析性能和用户友好性方面存在显著差异.
- 实施由中央实验室监督的强有力的质量保证计划对于可靠的POCT-CRP结果至关重要.
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