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Updated: Jul 18, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
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免疫性与工程T细胞受体细胞产品过程相关杂质的免疫性风险评估

Johanna Mora1, Daron Forman2, Jennifer Hu3

  • 1Clinical Pharmacology Pharmacometrics and Bioanalysis, Bristol Myers Squibb, Princeton, NJ, United States.

Journal of pharmaceutical sciences
|May 20, 2024
PubMed
概括

这项研究提供了一个框架,用于评估细胞疗法中剩余蛋白质试剂的免疫性风险,如腺相关病毒6 (AAV6) 和Cas9. 使用人类外周血液单核细胞 (PBMC) 的体外测定有助于确定这些关键过程残留物的安全暴露水平.

关键词:
一个AAV6一个AV6抗药物抗体 抗药物抗体这就是Cas9的情况.细胞疗法是一种细胞疗法.工程T细胞受体疗法 工程T细胞受体治疗免疫性 免疫性 免疫性剩余的 剩余的 剩余的风险评估 风险评估 风险评估

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Immunoprecipitation01:20

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...