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由L-PGDS/PGD2/Src信号功能障碍引起的星细胞缩在中央杏仁体中介于产后抑郁症

Zhihao Sheng1, Qidong Liu2, Yujie Song1

  • 1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.

Journal of affective disorders
|May 20, 2024
PubMed
概括

在小鼠中产后抑郁症 (PPD) 与中枢杏仁体中的前列腺素D2 (PGD2) 减少有关,导致星体缩和抑郁行为. 这突显了PPD中一种新的PGD2信号通路.

关键词:
星球细胞缩 星球细胞缩中央杏仁体中的一个.产后抑郁症 产后抑郁症孕腺素 D2 的前列腺素 D2酸的酸化是Src的酸化.

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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.