探索等离子体和抑郁症的无氧化指数之间的L形关系:来自NHANES 2005-2018年的结果
Haokun Zhang1, Genshan Zhang2, Jie Fu3
1Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; School of Public Health and Health Management, Gannan Medical University, Ganzhou 341000, PR China.
Journal of affective disorders
|May 20, 2024
概括
血的动脉生成指数 (AIP) 显示了美国成年人与抑郁症的L形联系. 保持较低的AIP水平可能有助于管理抑郁风险.
科学领域:
- 心血管健康 心血管健康
- 心理健康研究 心理健康研究
- 生物标志物发现发现
背景情况:
- 血大气原体指数 (AIP) 是一种与各种疾病相关的新兴指标.
- 有限的研究存在于AIP和抑郁症之间的关系.
- 这项研究调查了AIP和抑郁症之间的非线性关联.
研究的目的:
- 为了确定等离子体的无气性指数 (AIP) 和抑郁症之间的关联.
- 使用先进的统计模型探索AIP和抑郁症之间的非线性关系.
- 为了确定与抑郁风险相关的AIP的潜在门.
主要方法:
- 分析了2005-2018年国家健康和营养检查调查 (NHANES) 的12453名参与者.
- 使用log10 (三糖/高密度脂蛋白胆固醇) 计算AIP.
- 通过患者健康问卷 (PHQ-9) 识别抑郁症,得分≥10;统计分析包括加权后勤回归和限制立方线 (RCS).
主要成果:
- 在AIP和抑郁症之间观察到一个显著的L形关联.
- 较高的AIP水平与抑郁症的可能性增加有关 (OR=1.50).
- RCS分析显示,转折点为-0.289,超越该转折点后,抑郁症的几率显著增加 (OR=2.25),特别是在糖尿病患者中.
结论:
- 在美国成年人中,AIP和抑郁症之间存在L形关联.
- AIP可以作为抑郁症的有价值的生物标志物.
- 保持AIP低于特定值可能有助于抑郁症管理.
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