在多发性骨髓瘤中优化自身干细胞移植:强化化疗动的影响

相关实验视频

Updated: Jun 25, 2025

09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

8.7K

Andrew J Portuguese¹, Albert C Yeh¹, Rahul Banerjee¹

¹Fred Hutchinson Cancer Center, Seattle, Washington; University of Washington, Seattle, Washington.

Transplantation and cellular therapy

|May 20, 2024

概括

密集化疗动员 (ICM) 改善了经过自身干细胞移植的多发性骨髓瘤 (MM) 患者的无事件生存率,尽管感染和更长时间住院等短期毒性增加了.

科学领域:

血液学血液学血液学
在瘤学瘤学.
干细胞移植干细胞移植

背景情况:

使用G-CSF与按需的plerixafor (G ± P) 进行自身外周血液干细胞采集 (PBSC) 是可移植多发性骨髓瘤 (MM) 的标准.
化学动员 (CM) 可以在自主外周血液干细胞移植 (ASCT) 之前挽救G ± P失败或解体瘤负担.
以前的CM疗法 (例如基于环胺) 显示长期益处有限.

研究的目的:

评估密集化疗动员 (ICM) 对MM患者无事件生存 (EFS) 的影响.
在ASCT之前评估ICM在患有过度疾病负担的患者的疗效和毒性.

主要方法:

对451名新诊断的MM患者进行了回顾性研究,他们在2020年7月至2023年2月期间接受了ASCT.
使用密集的CM (基于PACE或HyperCVAD) 与使用倾向得分匹配 (PSM) 的非CM患者进行了比较.
EFS被定义为死亡,进展性疾病或未计划的治疗升级.

主要成果:

在PSM分析中,ICM与显著改善的EFS (HR 0.30,P = .003) 有关.
在ICM患者中,CD34+细胞收集的中位数较高 (10.8 vs 10.2 × 106/kg,P = .018).
ICM导致ASCT后的住院时间更长,发烧日更多,血小板移植受损,细菌病和抗生素使用增加.

结论:

强化化疗动员是独立相关的改善EFS在MM患者过度疾病负担.
必须权衡ICM的好处与短期毒性增加,包括感染和长时间住院治疗.
对于某些MM患者来说,ICM可能是一个可行的选择,需要仔细考虑风险和益处.

关键词:

自主造血干细胞移植自主造血干细胞移植化学动员化疗法化学动员化疗法多发性骨髓瘤是一种多发性骨髓瘤.倾向性得分匹配的匹配方法

相关概念视频

01:21

Stem Cell Therapy for Tissue Regeneration

4.0K

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

4.0K

01:22

Bone Marrow Sampling and Transplants

324

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

324

02:50

Combination Therapies and Personalized Medicine

4.9K

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...