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天然的 antraquinone 染料 emodin:水生生物的生态/基因毒理学表征

Natália Oliveira de Farias¹, Amanda Rocha Rodrigues², Marina Tenório Botelho²

¹Faculdade de Tecnologia, Universidade Estadual de Campinas, UNICAMP, Limeira, SP, Brazil; Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|May 20, 2024

概括

埃莫丁是一种天然染料,在水生生物如达芬尼亚和斑马鱼胚胎中表现出显著的毒性和变异性. 需要进一步的研究来了解其对环境的影响和毒性途径.

科学领域:

环境毒理学环境毒理学
生态毒理学生态毒理学
自然产品化学自然产品化学

背景情况:

埃莫丁是一种具有染色特性的植物衍生性 antraquinone.
埃莫丁使用的废水对环境构成风险.
有限的数据存在于emodin的水生毒性和突变性.

研究的目的:

评估emodin在水生生物中的生态/基因毒性.
为了识别对emodin敏感的水生物种.
为了确定emodin.的环境风险.

主要方法:

评估Daphnia similis和斑马鱼胚胎中的埃莫丁毒性.
在Raphidocelis subcapitata,Ceriodaphnia dubia和Parhyale hawaiensis中测试埃莫丁毒性.
通过细菌和体内试验评估emodin的突变性.

主要成果:

埃莫丁对达芬尼亚仿真菌 (EC50 = 130μg L-1) 和斑马鱼胚胎 (LC50 = 25μg L-1) 呈现出毒性.
在Raphidocelis subcapitata,Ceriodaphnia dubia或Parhyale hawaiensis中没有观察到任何毒性.
埃莫丁在细菌和P. hawaiensis微核试验中显示出致变性,PNEC为0.025μg L-1.1.

结论:

埃莫丁对关键的水生生物有毒和变异性.
埃莫丁代表了对水生物种最有毒的 antraquinone 染料.
需要进一步的研究来阐明emodin在水生环境中的毒性机制.

关键词:

达夫尼亚类似的植物生态毒性生态毒性基因毒性基因毒性微核是微核中的一个.帕哈耶尔 (Parhyale) 是一个夏威夷人.斑马鱼是一种斑马鱼.

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