与兴奋相关的皮质网络与神经活动和血液动力学有不同的联系
Lisa Meyer-Baese1,2, Arthur E Morrissette1, Yunmiao Wang1
1Department of Biology, Emory University, Atlanta, Georgia 30322.
概括
大脑兴奋会影响整个皮质区域的电压和血液动力活动. 虽然血液动力学信号与行为密切相关,但电压活动显示出明显的兴奋驱动模式,特别是在面部或面部运动期间.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 大脑表现出结构化的活动模式,即使没有外部刺激或任务.
- 兴奋水平显著调节这种内在的大脑活动.
- 了解兴奋和神经信号之间的关系对于破译大脑功能至关重要.
研究的目的:
- 为了研究刺激和皮质网络电压和小鼠血液动力学活动之间的关系.
- 为了确定兴奋如何影响电压和血液动力学信号的不同皮质区域.
- 探索与兴奋和行为有关的电压和血液动力学信号之间的连贯性和合模式.
主要方法:
- 在头部固定小鼠 (雄性和雌性) 中进行广场电压成像.
- 使用了电压敏感的光FRET传感器蝶 1.2.
- 分析自发大脑活动,兴奋调节和行为状态 (包括耳鼻面部运动).
主要成果:
- 全球电压和血液动力学信号与兴奋正相关 (最大相关性分别为0.5和0.25).
- 观察到刺激对电压和血液动力学信号有明显的皮层区域影响.
- 前额叶皮层显示电压 (正) 和血液动力学 (负) 信号与兴奋之间存在相反的相关性.
- 电压和血液动力学信号之间的一致性在低频率 (<0.15 Hz) 中最强.
- 合模式取决于行为状态,由 orofacial 运动驱动.
结论:
- 血液动力学信号与行为和兴奋有很强的相关性,但与电压活动有明显的区别.
- 皮层电压活动为与兴奋相关的神经动态提供了不同的视角.
- 兴奋对皮层区域的电压和血液动力学信号产生不同的影响.
- 行为状态,如面部或面部运动,显著塑造这些神经信号合.
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