在非常早产的婴儿中,维生素D缺乏的风险因素和结果
Hannah Cho1, Yoon Lee1, Saelin Oh2
1Department of Pediatrics, Korea University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Korea University Anam Hospital, Seoul, Republic of Korea.
Pediatrics and neonatology
|May 20, 2024
概括
非常早产的婴儿,长时间的亲肠道营养和低母乳摄入量,面临更高的维生素D缺乏症 (VDD) 风险. 这项研究确定了这一脆弱人群中VDD的关键风险因素.
科学领域:
- 新生儿科学 新生儿科学
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
背景情况:
- 维生素D对骨健康和免疫功能至关重要.
- 维生素D缺乏 (VDD) 对非常早产 (VP) 婴儿构成重大风险.
- 了解VP婴儿的VDD风险因素和结果对于有针对性的干预至关重要.
研究的目的:
- 调查导致非常早产婴儿VDD的危险因素.
- 在这个人群中探索与VDD相关的临床结果.
- 确定增加VP婴儿VDD风险的特定因素.
主要方法:
- 韩国首尔82名VP婴儿的回顾性队列研究 (2018年1月至2022年6月).
- 血清25-氧维生素D (25(OH) D水平测定在4-6周的年龄;VDD定义为<20 ng/mL.
- 在VDD和非VDD组之间比较产前/产后风险因素和临床结果.
主要成果:
- 32.9%的VP婴儿患有VDD.
- 长时间的亲肠道营养 (PN) 持续时间 (aOR=1.12) 和较低的母乳摄入量 (aOR=0.976) 是VDD的重要风险因素.
- VDD组显示较低的和较高的副甲状腺激素水平;恶心病的严重程度得分更高,但不显著.
结论:
- 延长PN持续时间是VP婴儿VDD的重要危险因素.
- 减少母乳摄入量与VP婴儿VDD风险增加有关.
- 早期识别和管理VDD风险因素对于VP婴儿健康至关重要.
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