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Updated: Jun 25, 2025

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在不受干扰的条件下,BRCA1/BARD1无处不在地化PCNA,以促进持续的DNA合成

Daniel Salas-Lloret1, Néstor García-Rodríguez2,3, Emily Soto-Hidalgo3

  • 1Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands.

Nature communications
|May 20, 2024
PubMed
概括

对于DNA修复或Olaparib耐药性来说,BRCA1/BARD1 E3活动并不必不可少. 然而,它使PCNA无处不在,防止DNA缺口和促进复制,突出其在同源重组中的作用.

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