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使用高重复率激光驱动的质子源生产用于PET临床前成像的碳-11

Juan Peñas¹, Aarón Alejo¹, Adrián Bembibre¹

¹Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

Scientific reports

|May 20, 2024

概括

研究人员展示了激光驱动的离子加速,用于产生碳-11放射性同位素,这是正电子发射断层扫描 (PET) 成像中的一个关键组成部分. 这种新的方法显示出 PET 标记剂生产更容易获得的前景.

科学领域:

核物理核物理核物理
医学成像技术医学成像技术
激光驱动的粒子加速器

背景情况:

pozitron-emission tomography (PET) 成像依赖于通常由传统粒子加速器产生的放射性同位素.
开发替代的,可能更容易获得的放射性同位素生产方法对于医疗诊断的进步至关重要.

研究的目的:

评估激光驱动的离子加速作为一种新技术,用于生产用于PET成像的碳-11放射性同位素.
为了证明使用高重复率激光系统用于多次射击放射性同位素生产的可行性.

主要方法:

使用PW级高重复率激光系统,以0.1-1赫兹的脉冲率将质子束加速到10-14MeV.
用B (p,n) C核反应辐射一个目标,产生碳-11.
使用多次射击操作方法测量放射性同位素活性.

主要成果:

通过25 J激光脉冲实现了234 kBq的碳-11活动峰值.
即使在较低的激光脉冲能量下,也证明了显著的碳-11生产.
测量活动与临床前PET成像要求相似.

结论:

激光驱动的离子加速是一种生产碳-11放射性同位素的可行方法.
将这项技术扩展到更高的重复率 (例如10 Hz) 可以满足临床PET成像需求.
未来激光技术的进步可能会使广泛的,可访问的PET标记器生产成为可能.

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