严重精神疾病和败血症和败血症休克死亡率:系统性审查和元分析
Ines Lakbar1,2, Eloise Maakaron3, Marc Leone4,5
1AP-HM, Aix-Marseille Univ, CEReSS, Health Service Research and Quality of Life Centre, School of Medicine - La Timone Medical, Marseille, France. ines.lakbar@chu-montpellier.fr.
Molecular psychiatry
|May 20, 2024
概括
患有严重精神疾病 (SMI) 的患者在被诊断为败血症或败血性休克时表现出生存优势. 这一系统性审查发现,与没有SMI的患者相比,SMI患者的病例死亡率较低.
科学领域:
- 医学研究 医学研究
- 临床结果 临床结果
- 公共卫生 公共卫生
背景情况:
- 关于严重精神疾病 (SMI) 患者的败血症和败血症休克结果存在相互矛盾的报道.
- 了解这些结果对于患者护理和公共卫生倡议至关重要.
研究的目的:
- 系统地审查和分析严重精神疾病 (SMI) 和没有严重精神疾病 (SMI) 的成年患者中败血症和败血性休克的病例死亡率.
主要方法:
- 搜索了Medline,科学网和科克兰图书馆数据库,直到2023年7月.
- 包括比较SMI (病例) 与没有SMI (对照) 的成年患者关于败血症和败血性休克结果的研究.
- 主要结果:未调整的病例死亡率;次要结果:调整的病例死亡率.
主要成果:
- 包括6项研究,其中4项对超过210万名患者的元分析做出了贡献.
- 患有SMI的患者年轻,女性更常见.
- 在SMI患者中,败血症和败血性休克的未调整病例死亡率较低 (OR 0.61,95% CI [0.58-0.65]).
- 超回归表明研究群体分母 (败血症与败血症休克) 影响了结果 (R2=59.7%).
结论:
- 患有严重精神疾病 (SMI) 的患者在败血症和败血性休克中表现出生存优势.
- 需要进一步的研究,以了解潜在的机制,并为所有患者开发针对性的干预措施.
- 改善败血症预后需要了解导致SMI群体结果差异的因素.
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