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Updated: Jun 25, 2025

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

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通过HGSNAT进行 lysosome 跨膜乙化的结构和机制

Ruisheng Xu1,2, Yingjie Ning3, Fandong Ren1

  • 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Nature structural & molecular biology
|May 20, 2024
PubMed
概括

现在已经理解了溶酶体跨膜乙化,这对于肝酸硫酸盐降解和预防疾病至关重要. 冷-EM结构显示HGSNAT形成了一个道,使得乙-CoA能够穿过膜并修改肝硫酸盐.

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Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli07:26

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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Export of Misfolded Proteins out of the ER

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