脂肪细胞HSL是保持在禁食期间循环维生素A和RBP4水平所需的
Julia S Steinhoff1, Carina Wagner2, Henriette E Dähnhardt1
1Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany.
EMBO reports
|May 20, 2024
概括
禁食会耗尽维生素A的储量,但脂肪组织中的激素敏感脂酶 (HSL) 有助于维持血液中的视网醇和RBP4水平. 脂肪细胞中的HSL对于禁食期间维生素A的平衡至关重要.
科学领域:
- 代谢过程中的代谢.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素A (视网醇) 的运输依赖于视网醇结合蛋白4 (RBP4),主要从肝脏储存中调动.
- 肝外维生素A储存在维持血清视网醇和RBP4水平的作用在像禁食这样的生理压力期间还不清楚.
研究的目的:
- 研究肝外组织,特别是脂肪组织在禁食期间对维生素A稳态的贡献.
- 阐明调节脂肪组织中的视网膜蛋白调动的分子机制.
主要方法:
- 使用了具有全球或脂肪细胞特异性荷尔蒙敏感脂酶 (HSL) 缺陷的小鼠模型.
- 在禁食条件下分析了血清和组织的视网水平,RBP4度和视网反应性基因表达.
主要成果:
- 禁食会诱导组织特异性的视网体动员,脂肪组织起着关键作用.
- 脂肪细胞中的激素敏感脂酶 (HSL) 对于释放视网醇至关重要,以应对没有视网醇的apo-RBP4.
- 脂肪组织中的HSL缺乏导致脂肪中的视网积,并在禁食期间降低血清视网和RBP4,影响眼睛和脏等点组织.
结论:
- 脂肪组织在禁食期间作为维生素A的关键肝外储存库.
- 通过HSL介导的肝脏和脂肪组织视网膜体储存之间的新型交叉交互对于维持全身维生素A平衡至关重要.
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