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基于脂质的胰岛素抵抗标志物预测了与代谢功能障碍相关的脂肪性肝病相关的心血管事件
Alessandra Colantoni1,2, Tommaso Bucci3,4, Nicholas Cocomello1,2
1Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
对IR (HOMA-IR) 和脂质积累产品 (LAP) 的同静态模型评估最能确定代谢功能障碍相关的脂肪性肝病 (MASLD). 基于脂质的标记物可能有助于对MASLD患者的心血管风险进行分层,这需要进一步研究.
科学领域:
- 代谢功能障碍相关的脂肪性肝病 (MASLD)
- 心血管疾病 心血管疾病
- 胰岛素耐药性 胰岛素耐药性是一种
背景情况:
- 胰岛素抵抗 (IR) 是MASLD的核心,将其与代谢和心血管疾病 (CVD) 联系起来.
- 没有前性研究比较了用于预测MASLD和心血管事件 (CVE) 风险的IR标志物.
研究的目的:
- 在识别MASLD时,比较各种IR标记物的预测值.
- 评估IR标志物与MASLD患者中CVE风险之间的关联.
主要方法:
- 对前性普利尼奥研究在失能患者中的后期分析.
- 对IR (HOMA-IR),甘油三-血糖 (TyG) 指数,甘油三与高密度脂蛋白胆固醇比率 (TG/HDL-C),脂质积累产物 (LAP) 和内脏肥胖指数 (VAI) 的评估均质模型评估.
- 使用ROC分析以找到最佳切线和多变量回归来评估与MASLD和CVE风险的关联.
主要成果:
- 在检测MASLD时,HOMA-IR (AUC:0.792) 和LAP (AUC:0.787) 显示了最高的准确性.
- 在MASLD患者中,TyG指数,LAP,TG/HDL-C和VAI显示了可比,适度的预测值,用于MASLD患者的CVE风险 (AUC从0.590到0.630不等).
结论:
- HOMA-IR和LAP是检测异能代谢患者中MASLD最准确的标记物.
- 需要在更大的队列中进一步验证,以确认基于脂质的IR标记在MASLD中对心血管风险分层的有用性.
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